Ca2+ and cAMP cross‐talk in mitochondria. (29th August 2013)

• Record Type: Journal Article
• Authors: Di, Giulietta; Pendin, Diana; Greotti, Elisa; Pizzo, Paola; Pozzan, Tullio
• Is Part Of: Journal of physiology. Volume 592:Number 2(2014:Jan.)
• Page Start: 305
• Page End: 312
• Publication Date: 2013-08-29
• Subjects: Physiology -- Periodicals; 612.005
• DOI: 10.1113/jphysiol.2013.259135
• Languages: English
• ISSNs: 0022-3751

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>While mitochondrial Ca²⁺ homeostasis has been studied for several decades and many of the functional roles of Ca²⁺ accumulation within the matrix have been at least partially clarified, the possibility of modulation of the organelle functions by cAMP remains largely unknown. In this contribution we briefly summarize the key aspects of Ca²⁺ and cAMP signalling pathways in mitochondria. In particular, we focus on recent findings concerning the discovery of an autonomous cAMP toolkit within the mitochondrial matrix, its crossroad with mitochondrial Ca²⁺ signalling and its role in controlling ATP synthesis. The discovery of a cAMP signalling, and the demonstration of a cross‐talk between cAMP and Ca²⁺ inside mitochondria, open the way to a re‐evaluation of these organelles as integrators of multiple second messengers. A description of the main methods presently available to measure Ca²⁺ and cAMP in mitochondria of living cells with genetically encoded probes is also presented.</p> </abstract>