Comparative study of select biochemical markers in cerebrospinal fluid of healthy dogs before and after treatment with nutraceuticals. (28th January 2014)

• Record Type: Journal Article
• Authors: Galan, A.; Carletti, B.E.; Morgaz, J.; Granados, M.M.; Mesa, I.; Navarrete, R.; Lombardo, R.; Martínez, C.M.; Martín‐Suárez, E.M.
• Is Part Of: Veterinary clinical pathology. Volume 43:Number 1(2014)
• Page Start: 72
• Page End: 77
• Publication Date: 2014-01-28
• Subjects: Veterinary pathology -- Periodicals; 636.089607
• DOI: 10.1111/vcp.12109
• Languages: English
• ISSNs: 0275-6382

Abstract

<abstract abstract-type="main" id="vcp12109-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="vcp12109-sec-0001" sec-type="section"> <title>Background</title> <p>Several studies indicate that changes in cerebrospinal fluid (CSF) composition depend on the disease stage and reflect modification of brain energy metabolism (BEM). Also, it has been reported that a decline in cognitive functions may be mitigated by incorporating nutraceuticals in the diet.</p> </sec> <sec id="vcp12109-sec-0002" sec-type="section"> <title>Objective</title> <p>Assuming the beneficial effect of nutraceuticals on BEM and oxidative damage, the aim of this study was to determine if the administration of a nutraceutical compound results in changes of select CSF biomarkers in healthy adult Beagle dogs.</p> </sec> <sec id="vcp12109-sec-0003" sec-type="section"> <title>Methods</title> <p>Two separate CSF and blood samples were obtained from 11 healthy adult Beagle dogs, before and after 50 days of treatment with a veterinary combined nutraceutical. CSF analysis included a total nucleated cell count, total protein, glucose, sodium, chloride, potassium, pyruvate, and lactate concentrations, and calculation of lactate/pyruvate ratio. CBC and serum biochemistry were also performed. The Wilcoxon test was used to analyze the significance of the changes after nutraceutical treatment.</p> </sec> <sec id="vcp12109-sec-0004" sec-type="section"> <title>Results</title> <p>All studied variables remained within reference intervals, before and after treatment. A significant increase in CSF sodium and glucose concentration, and a decrease in lactate levels, was observed after treatment (<italic>P </italic>< .05), and the lactate/pyruvate ratio was decreased after treatment (<italic>P </italic>= .05). In serum, sodium and chloride concentrations were significantly increased (<italic>P </italic>< .05), and creatinine concentration was significantly decreased (<italic>P </italic>< .05) after treatment.</p> </sec> <sec id="vcp12109-sec-0005" sec-type="section"> <title>Conclusions</title> <p>After 50 days of treatment with a nutraceutical compound, CSF glucose, sodium, and lactate concentrations, and L/P ratio were significantly different, suggesting an influence of nutraceuticals' administration on CSF composition.</p> </sec> </abstract>