Specific IgG4: Possible Role in the Pathogenesis and a New Marker in the Diagnosis of Anisakis‐associated Allergic Disease. (February 2014)

• Record Type: Journal Article
• Authors: Daschner, A.; Fernández‐Fígares, V.; Rodero, M.; Valls, A.; De Frutos, C.; Ubeira, F. M.; Cuéllar, C.
• Is Part Of: Scandinavian journal of immunology. Volume 79:Number 2(2014:Feb.)
• Page Start: 120
• Page End: 126
• Publication Date: 2014-02
• Subjects: Immunology -- Periodicals; 571.96
• DOI: 10.1111/sji.12129
• Languages: English
• ISSNs: 0300-9475

Abstract

<abstract abstract-type="main" id="sji12129-abs-0001"> <title>Abstract</title> <p>IgG<sub>4</sub> and IgE are immunoglobulin isotypes which are mediated by the same Th2‐mediated mechanism. The postulated pathogenic and protective function of IgE or IgG<sub>4, </sub> respectively, in allergic disease is opposite in parasitic infection. The possible role of IgG<sub>4</sub> against recombinant major allergens on the appearance of different forms of <italic>Anisakis simplex</italic>‐associated allergic disease was studied. Gastro‐allergic anisakiasis (GAA) and <italic>Anisakis</italic>‐sensitization‐associated chronic urticaria (CU+) were compared for specific IgE, IgG<sub>4</sub> and the respective recognition of <italic>Ani s 1</italic> and <italic>Ani s 7</italic>. Gastro‐allergic anisakiasis showed higher IgE and IgG<sub>4</sub> levels against crude extract and both recombinant allergens. Whereas IgE recognition of <italic>Ani s 7</italic> did not differ and supports both clinical entities to be associated with previous acute parasitism, the IgE recognition rates of <italic>Ani s 1</italic> and IgG<sub>4</sub> recognition of both <italic>Ani s 1</italic> and <italic>Ani s 7</italic> were higher in GAA. IgG<sub>4</sub> levels were associated with IgE, but also with age, time to last parasitic episode and frequency of fish intake. Logistic regression analysis showed that the presence of specific IgG<sub>4</sub> against <italic>Ani s 7</italic> was an independent marker associated with GAA. In the diagnosis of <italic>Anisakis</italic>‐associated allergic disease phenotypes (GAA versus CU+), measurement of specific IgG<sub>4</sub> against recombinant allergens could be useful. Further, evaluation of specific IgE and IgG<sub>4</sub> facilitates more insight into the protective versus pathogenic potential of IgE and IgG<sub>4</sub><sub>.</sub></p> </abstract>