Sleep deprivation in humans: Effects on melatonin in cerebrospinal fluid and serum. Issue 1 (7th January 2014)

• Record Type: Journal Article
• Authors: Bumb, Jan Malte; Schwarz, Emanuel; Enning, Frank; Rohleder, Cathrin; Findeisen, Peter; Leweke, F Markus; Noelte, Ingo
• Is Part Of: Sleep and biological rhythms. Volume 12:Issue 1(2014)
• Page Start: 69
• Page End: 72
• Publication Date: 2014-01-07
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sleep-wake cycle -- Periodicals; 612.82105
• DOI: 10.1111/sbr.12039
• Languages: English
• ISSNs: 1446-9235

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Blood, urinary and saliva melatonin levels have been found to be associated with sleep disturbances and sleep deprivation. Melatonin responses to sleep deprivation have not been examined in cerebrospinal fluid (CSF) of healthy individuals. In this study, we measured CSF and serum melatonin before and after one night of sleep deprivation using enzyme linked immunosorbent assay. Melatonin levels increased in both CSF (+142%) as well as serum (+75%) after sleep deprivation but lacked correlation between both body fluids. These findings support melatonin's central role for regulating sleep processes.</p> </abstract>