Early Pregnancy Changes in Bacterial Vaginosis‐Associated Bacteria and Preterm Delivery. Issue 2 (9th January 2014)

• Record Type: Journal Article
• Authors: Nelson, Deborah B.; Hanlon, Alexandra; Nachamkin, Irving; Haggerty, Catherine; Mastrogiannis, Dimitrios S.; Liu, Congzhou; Fredricks, David N.
• Is Part Of: Paediatric and perinatal epidemiology. Volume 28:Issue 2(2014)
• Page Start: 88
• Page End: 96
• Publication Date: 2014-01-09
• Subjects: Pediatrics -- Periodicals; Perinatology -- Periodicals; Pediatric epidemiology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; 618.92
• DOI: 10.1111/ppe.12106
• Languages: English
• ISSNs: 0269-5022

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="ppe12106-sec-0001" sec-type="section"> <title>Background</title> <p>We evaluated the importance of measuring early vaginal levels of eight bacterial vaginosis (BV)‐associated bacteria, at two points in pregnancy, and the risk of spontaneous preterm delivery (SPTD) among pregnant women and the subgroup of pregnant women with a history of preterm delivery (PTD).</p> </sec> <sec id="ppe12106-sec-0002" sec-type="section"> <title>Methods</title> <p>This prospective cohort study enrolled women at five urban obstetric practices at Temple University Hospital in Philadelphia PA. Women with singleton pregnancies less than 16 weeks gestation self‐collected vaginal swabs at two points in pregnancy, prior to 16 weeks gestation and between 20–24 weeks gestation, to measure the presence and level of eight BV‐associated bacteria. Women were followed‐up for gestational age at delivery via medical records.</p> </sec> <sec id="ppe12106-sec-0003" sec-type="section"> <title>Results</title> <p>Among women reporting a prior PTD, women with higher levels of <italic>L</italic><italic>eptotrichia/</italic><italic>S</italic><italic>neathia species</italic>, BVAB1 and <italic>M</italic><italic>obiluncus spp.</italic>, prior to 16 weeks gestation, were significantly more likely to experience a SPTD. In addition, pregnant women with a prior PTD and increasing levels of <italic>L</italic><italic>eptotrichia/</italic><italic>S</italic><italic>neathia species</italic> (aOR: 9.1, 95% CI 1.9, 42.9), BVAB1 (aOR: 16.4, 95% CI 4.3, 62.7) or <italic>M</italic><italic>egasphaera phylotype 1</italic> (aOR: 6.2, 95% CI 1.9, 20.6), through 24 weeks gestation, were significantly more likely to experience an SPTD. Among the overall group of pregnant women, the levels of BV‐associated bacteria were not related to SPTD.</p> </sec> <sec id="ppe12106-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Among the group of women reporting a prior PTD, increasing levels of BVAB1, <italic>L</italic><italic>eptotrichia/</italic><italic>S</italic><italic>neathia species</italic>, and <italic>M</italic><italic>egasphaera phylotype 1</italic>, through mid‐pregnancy were related to an increased risk of SPTD.</p> </sec> </abstract>