Bedside Ultrasound‐Guided Celiac Plexus Neurolysis in Upper Abdominal Cancer Patients: A Randomized, Prospective Study for Comparison of Percutaneous Bilateral Paramedian vs. Unilateral Paramedian Needle‐Insertion Technique. Issue 2 (15th August 2013)

• Record Type: Journal Article
• Authors: Bhatnagar, Sushma; Joshi, Saurabh; Rana, S.P.S.; Mishra, Seema; Garg, Rakesh; Ahmed, Syed M.
• Is Part Of: Pain practice. Volume 14:Issue 2(2014)
• Page Start: E63
• Page End: E68
• Publication Date: 2013-08-15
• Subjects: Pain -- Treatment -- Periodicals; 616.0472
• DOI: 10.1111/papr.12107
• Languages: English
• ISSNs: 1530-7085

Abstract

<abstract abstract-type="main" id="papr12107-abs-0001"> <title>Abstract</title> <sec id="papr12107-sec-0001" sec-type="section"> <title>Introduction</title> <p>Percutaneous anterior abdominal ultrasound guidance for performing celiac plexus neurolysis is a relatively new but more economical, less time‐consuming, more comfortable bedside technique for interventional pain management. Paucity of studies evaluating the efficacy of single‐site vs. double‐site injections at celiac trunk for ultrasound‐guided celiac plexus neurolysis (USCPN) prompted us to conduct a prospective, randomized, single‐blind clinical trial to compare USCPN using bilateral paramedian (double needle) technique with unilateral paramedian (single needle) technique.</p> </sec> <sec id="papr12107-sec-0002" sec-type="section"> <title>Methods</title> <p>Sixty patients aged 18 years or older with unresectable upper abdominal cancers were randomized into two groups to receive USCPN. A 20‐mL mixture of 50% ethanol with 0.25% bupivacaine was injected either unilaterally (20 mL×1 site) or bilaterally (10 mL×2 sites) depending on the randomization group. Subjects were assessed for the pain relief using Numerical rating scale (NRS) to assess their pain relief.</p> </sec> <sec id="papr12107-sec-0003" sec-type="section"> <title>Results</title> <p>Baseline parameters being comparable (<italic>P</italic> > 0.05), the site of drug injections (single or double needle) had no bearing on the onset of pain relief and patient satisfaction scores (<italic>P</italic> > 0.05). Pain relief during follow‐up visits was comparable between the two groups (<italic>P</italic> > 0.05). The discomfort score correlated well with the pain relief scoring without any significant difference between the two groups except in the last visit (at 3 month). Incidences of the complications were comparable in the two groups (<italic>P</italic> > 0.05).</p> </sec> <sec id="papr12107-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Ultrasound‐guided celiac plexus neurolysis using unilateral paramedian (single needle) needle‐insertion technique is comparable with bilateral paramedian (double needle) needle‐insertion technique with regard to pain relief and side effects.</p> </sec> </abstract>