Interleukin‐4RA gene polymorphism is associated with oral mucous membrane pemphigoid. (5th April 2013)

• Record Type: Journal Article
• Authors: Carrozzo, M; Dametto, E; Fasano, ME; Broccoletti, R; Carbone, M; Rendine, S; Amoroso, A
• Is Part Of: Oral diseases. Volume 20:Number 3(2014:Apr.)
• Page Start: 275
• Page End: 280
• Publication Date: 2013-04-05
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12106
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12106-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12106-sec-0001" sec-type="section"> <title>Objective</title> <p>The aim of this study was to analyse whether the polymorphisms of several pro‐ and anti‐inflammatory cytokines may influence the susceptibility to predominantly oral Mucous membrane pemphigoid (MMP) in a Northern Italian population.</p> </sec> <sec id="odi12106-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>DNA was obtained from 41 MMP patients (29 with exclusively oral pemphigoid [OP]) and 140 unrelated bone marrow donors. Thirteen cytokine genes with 22 single‐nucleotide polymorphisms (SNP) were studied by a sequence‐specific PCR assay.</p> </sec> <sec id="odi12106-sec-0003" sec-type="section"> <title>Results</title> <p>There was no significant difference between the patients taken together and healthy controls for any cytokine gene polymorphism studied. However, the allele A of the IL‐4 receptor A (IL‐4RA) was significantly more frequent in OP than controls (<italic>P</italic> < 0.05), causing an increased frequency of genotype A/A in OP patients (89.7 <italic>vs</italic> 67.9, odds ratio: 4.11, 95% confidence intervals 1.18–14.28, <italic>P</italic> = 0.023, Pc = 0.046).</p> </sec> <sec id="odi12106-sec-0004" sec-type="section"> <title>Conclusion</title> <p>IL‐4RA‐1902 A/A genotype has been associated with a reduced response to IL‐4 and has been found in 90% OP patient. Giving the supposed importance of IL‐4 in MMP fibrotic process, our results can partially explain the low likelihood of scarring in OP patients.</p> </sec> </abstract>