Fatal breakthrough infection with Fusarium andiyazi: new multi‐resistant aetiological agent cross‐reacting with Aspergillus galactomannan enzyme immunoassay. Issue 4 (6th October 2013)

• Record Type: Journal Article
• Authors: Kebabcı, Nesrin; van, Anne D.; Ener, Beyza; Ersal, Tuba; Meijer, Martin; Al‐Hatmi, Abdullah M.S.; Özkocaman, Vildan; Ursavaş, Ahmet; Çetinoğlu, Ezgi D.; Akalın, Halis
• Is Part Of: Mycoses. Volume 57:Issue 4(2014)
• Page Start: 249
• Page End: 255
• Publication Date: 2013-10-06
• Subjects: Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12142
• Languages: English
• ISSNs: 0933-7407

Abstract

<abstract abstract-type="main" id="myc12142-abs-0001"> <title>Summary</title> <p>Disseminated infections caused by members of the <italic>Fusarium fujikuroi</italic> species complex (FFSC) occur regularly in immunocompromised patients. Here, we present the first human case caused by FFSC<italic>‐</italic>member <italic>Fusarium</italic> andiyazi. Fever, respiratory symptoms and abnormal computerised tomography findings developed in a 65‐year‐old man with acute myelogenous leukaemia who was under posaconazole prophylaxis during his remission–induction chemotherapy. During the course of infection, two consecutive blood galactomannan values were found to be positive, and two blood cultures yielded strains resembling <italic>Fusarium</italic> species, according to morphological appearance. The aetiological agent proved to be <italic>F. andiyazi</italic> based on multilocus sequence typing. The sequencing of the internal transcribed spacer region did not resolve the closely related members of the FFSC, but additional data on partial sequence of transcription elongation factor 1 alpha subunit did. A detailed morphological study confirmed the identification of <italic>F. andiyazi, </italic> which had previously only been reported as a plant pathogen affecting various food crops.</p> </abstract>