Anticonvulsant activity of Aloe vera leaf extract in acute and chronic models of epilepsy in mice. (20th November 2013)

• Record Type: Journal Article
• Authors: Rathor, Naveen; Arora, Tarun; Manocha, Sachin; Patil, Amol N.; Mediratta, Pramod K.; Sharma, Krishna K.
• Is Part Of: Journal of pharmacy and pharmacology. Volume 66:Number 3(2014:Mar.)
• Page Start: 477
• Page End: 485
• Publication Date: 2013-11-20
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12181
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12181-sec-0001" sec-type="section"> <title>Objectives</title> <p>The effect of <italic>Aloe vera</italic> in epilepsy has not yet been explored. This study was done to explore the effect of aqueous extract of <italic>Aloe vera</italic> leaf powder on three acute and one chronic model of epilepsy.</p> </sec> <sec id="jphp12181-sec-0002" sec-type="section"> <title>Methods</title> <p>In acute study, aqueous extract of <italic>Aloe vera</italic> leaf (extract) powder was administered in doses 100, 200 and 400 mg/kg p.o. Dose of 400 mg/kg of <italic>Aloe vera</italic> leaf extract was chosen for chronic administration. Oxidative stress parameters viz. malondialdehyde (MDA) and reduced glutathione (GSH) were also estimated in brain of kindled animals.</p> </sec> <sec id="jphp12181-sec-0003" sec-type="section"> <title>Key findings</title> <p>In acute study, <italic>Aloe vera</italic> leaf (extract) powder in a dose‐dependent manner significantly decreased duration of tonic hind limb extension in maximal electroshock seizure model, increased seizure threshold current in increasing current electroshock seizure model, and increased latency to onset and decreased duration of clonic convulsion in pentylenetetrazole (PTZ) model as compared with control group. In chronic study, <italic>Aloe vera</italic> leaf (extract) powder prevented progression of kindling in PTZ‐kindled mice. <italic>Aloe vera</italic> leaf (extract) powder 400 mg/kg p.o. also reduced brain levels of MDA and increased GSH levels as compared to the PTZ‐kindled non‐treated group.</p> </sec> <sec id="jphp12181-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The results of study showed that <italic>Aloe vera</italic> leaf (extract) powder possessed significant anticonvulsant and anti‐oxidant activity.</p> </sec> </abstract>