Metallothionein immunoexpression in selected benign epithelial odontogenic tumors. (11th October 2013)

• Record Type: Journal Article
• Authors: Johann, Aline Cristina Batista Rodrigues; Caldeira, Patrícia Carlos; Souto, Giovanna Ribeiro; de, Mauro Henrique Nogueira Guimarães; Aguiar, Maria Cássia Ferreira; Mesquita, Ricardo Alves
• Is Part Of: Journal of oral pathology & medicine. Volume 43:Number 3(2014:Mar.)
• Page Start: 177
• Page End: 182
• Publication Date: 2013-10-11
• Subjects: Dentistry -- Periodicals; Teeth -- Diseases -- Periodicals; 617
• DOI: 10.1111/jop.12122
• Languages: English
• ISSNs: 0904-2512

Abstract

<abstract abstract-type="main" id="jop12122-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jop12122-sec-0001" sec-type="section"> <title>Background</title> <p>Odontogenic tumors exhibited variable biologica behaviors. Metallothionein (MT) is correlated with the cellular homeostasis of essential metals, cellular differentiation, and proliferation. The core goals of this study are (i) to report and to compare MT expression among benign epithelial odontogenic tumors; (ii) to correlate MT with cellular proliferation index; and (iii) to evaluate the influence of the inflammatory infiltrate on MT expression.</p> </sec> <sec id="jop12122-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Ten cases of solid ameloblastomas (SABs), 4 squamous odontogenic tumors (SOTs), 5 adenomatoid odontogenic tumors (AOTs), and 3 calcifying epithelial odontogenic tumors (CEOTs) were subjected to immunohistochemical to anti‐MT, anti‐Ki‐67, and anti‐PCNA. Statistical analysis was performed using BioEstat<sup>®</sup> 4.0.</p> </sec> <sec id="jop12122-sec-0003" sec-type="section"> <title>Results</title> <p>Metallothionein staining was found to be the highest in the SABs (93.1%), followed by SOTs (52.9%), AOTs (38.4%), and CEOTs (0%). MT staining exhibited statistically significant differences between the SABs and the SOTs (<italic>P</italic> = 0.0047) and the AOTs (<italic>P</italic> = 0.0022). A weak‐to‐strong positive correlation between IMT and IK or IP was observed in SABs and SOTs, whereas a strong negative correlation was observed in AOTs. No differences in IMT, IK, and IP were observed between inflammation groups A and B.</p> </sec> <sec id="jop12122-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The increased MT expression observed in the SABs might be correlated with clinical behavior (local invasiveness and high rate of recurrence). In the SABs and SOTs, MT plays a role in the stimulation of cellular proliferation. In contrast, MT can inhibit cellular proliferation in the AOT. The IMT, IK, and IP are not affected by inflammation.</p> </sec> </abstract>