Associations Between Serum 25‐Hydroxyvitamin D Concentrations and Multiple Health Conditions, Physical Performance Measures, Disability, and All‐Cause Mortality: The Concord Health and Ageing in Men Project. Issue 3 (27th February 2014)

• Record Type: Journal Article
• Authors: Hirani, Vasant; Cumming, Robert G.; Naganathan, Vasi; Blyth, Fiona; Le Couteur, David G.; Handelsman, David J.; Waite, Louise M.; Seibel, Markus J.
• Is Part Of: Journal of the American Geriatrics Society. Volume 62:Issue 3(2014:Mar.)
• Page Start: 417
• Page End: 425
• Publication Date: 2014-02-27
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.12693
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs12693-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs12693-sec-0001" sec-type="section"> <title>Objectives</title> <p>To explore associations between serum 25‐hydroxyvitamin D <bold>(</bold>25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations.</p> </sec> <sec id="jgs12693-sec-0002" sec-type="section"> <title>Design</title> <p>Cross‐sectional study, with additional prospective data on falls and mortality.</p> </sec> <sec id="jgs12693-sec-0003" sec-type="section"> <title>Setting</title> <p>Concord Health and Ageing in Men Project, Sydney, Australia.</p> </sec> <sec id="jgs12693-sec-0004" sec-type="section"> <title>Participants</title> <p>Community‐dwelling men aged 70 and older (N = 1, 659).</p> </sec> <sec id="jgs12693-sec-0005" sec-type="section"> <title>Measurements</title> <p>Serum 25(OH)D levels, general health status, self‐reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls.</p> </sec> <sec id="jgs12693-sec-0006" sec-type="section"> <title>Results</title> <p>Fair, poor, and very poor health; self‐reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all‐cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater.</p> </sec> <sec id="jgs12693-sec-0007" sec-type="section"> <title>Conclusion</title> <p>Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.</p> </sec> </abstract>