Sitafloxacin‐based third‐line rescue regimens for Helicobacter pylori infection in Japan. Issue 3 (March 2014)

• Record Type: Journal Article
• Authors: Furuta, Takahisa; Sugimoto, Mitsushige; Kodaira, Chise; Nishino, Masafumi; Yamade, Mihoko; Uotani, Takahiro; Sahara, Shu; Ichikawa, Hitomi; Yamada, Takanori; Osawa, Satoshi; Sugimoto, Ken; Watanabe, Hiroshi; Umemura, Kazuo
• Is Part Of: Journal of gastroenterology and hepatology. Volume 29:Issue 3(2014:Mar.)
• Page Start: 487
• Page End: 493
• Publication Date: 2014-03
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12442
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstracts</title> <sec id="jgh12442-sec-0001" sec-type="section"> <title>Backgrounds</title> <p>Quinolone‐based regimens have been used as the rescue for eradication of <italic>Helicobacter pylori</italic>. Sitafloxacin is known to have low minimum inhibitory concentration for <italic>H. pylori.</italic> Here, we compared two sitafloxacin‐based eradication regimens as rescue for the eradication of <italic>H. pylori</italic>.</p> </sec> <sec id="jgh12442-sec-0002" sec-type="section"> <title>Methods</title> <p>We attempted to eradicate <italic>H. pylori</italic> in 180 Japanese patients who had never failed in eradication of <italic>H. pylori</italic> with the triple proton pump inhibitor/amoxicillin/clarithromycin therapy (1st line) and the triple proton pump inhibitor/amoxicillin/metronidazole therapy (2nd line). They were assigned to either the triple therapy with rabeprazole 10 mg b.i.d./q.i.d., amoxicillin 500 mg q.i.d, and sitafloxacin 100 mg b.i.d. (RAS) for 1 or 2 weeks or the triple therapy with rabeprazole 10 mg b.i.d./q.i.d., metronidazole 250 mg b.i.d., and sitafloxacin 100 mg b.i.d. (RMS) for 1 or 2 weeks. Eradication was assessed via the <sup>13</sup>C‐urea breath test and rapid urease test.</p> </sec> <sec id="jgh12442-sec-0003" sec-type="section"> <title>Results</title> <p>Intention‐to‐treat and per‐protocol analyses of eradication rates were 84.1% (37/44) and 86.4% (37/43) with RAS for 1 week, 88.9% (40/45) and 90.9% (40/44) for RAS for 2 weeks, 90.9% (40/44) and 90.9% (40/44) for 1 week‐RMS and 87.2% (41/47) and 91.1% (41/45) with RMS for 2 weeks. We noted no statistical significant differences in eradication rates among four regimens.</p> </sec> <sec id="jgh12442-sec-0004" sec-type="section"> <title>Conclusion</title> <p>All of the above‐described rescue regimens proved relatively equally useful in the eradication of <italic>H. pylori.</italic> Of them, RAS for 2 weeks and RMS for 1 or 2 weeks could attain the rescue eradication rates higher than 90% by per‐protocol analysis.</p> </sec> </abstract>