Clinical outcomes of a cohort series of patients with hepatocellular carcinoma in a hepatitis B virus‐endemic area. Issue 4 (April 2014)

• Record Type: Journal Article
• Authors: Kwak, Hee‐Won; Park, Joong‐Won; Nam, Byung‐Ho; Yu, Ami; Woo, Sang Myung; Kim, Tae Hyun; Kim, Seong Hoon; Koh, Young Hwan; Kim, Hyun Beom; Park, Sang Jae; Lee, Woo Jin; Hong, Eun Kyung; Kim, Chang‐Min
• Is Part Of: Journal of gastroenterology and hepatology. Volume 29:Issue 4(2014:Apr.)
• Page Start: 820
• Page End: 829
• Publication Date: 2014-04
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12470
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12470-sec-0001" sec-type="section"> <title>Background and Aims</title> <p>To evaluate the clinical outcomes of patients with hepatocellular carcinoma (HCC) and compare the findings with that of a previous cohort.</p> </sec> <sec id="jgh12470-sec-0002" sec-type="section"> <title>Methods</title> <p>Overall, 1972 HCC patients diagnosed and treated at the National Cancer Center, Korea between 2004 and 2009 were enrolled. The data of this cohort were compared with those of a previous cohort (2000–2003) from the same institution.</p> </sec> <sec id="jgh12470-sec-0003" sec-type="section"> <title>Results</title> <p>In all (mean age, 56.4 years; 1642 men), 74.6% was hepatitis B virus (HBV) positive, 81.6% were Child–Pugh (CP) class A, and 64.4% was Barcelona Clinic Liver Cancer (BCLC) stage C. The modified Union for International Cancer Control (mUICC) stage I, II, III, IVa, and IVb was found in 8.9%, 29.6%, 24.8%, 23.1%, and 13.6% patients, respectively. The most common initial treatment was transarterial chemotherapy (58.3%), followed by resection (18.6%). The 5‐year survival rate of BCLC stage 0, A, B, and C were 79.6%, 67.2%, 33.9%, and 17.1%, respectively. The performance status, BCLC stage, mUICC stage, CP class, model for end‐stage liver disease score, tumor characteristics, portal vein tumor invasion, and serum alpha‐fetoprotein level proved to be independent prognostic variables. Overall survival in the present cohort was better than that in the previous cohort (hazard ratio, 0.829; 95% confidence interval, 0.754–0.912), especially for advanced HCC patients with HBV‐positive status.</p> </sec> <sec id="jgh12470-sec-0004" sec-type="section"> <title>Conclusions</title> <p>This cohort study provides valuable insights into the characteristics of HCC in Korean patients. Our findings may help develop clinical trials, treatment strategies, and prognosis systems for HCC patients in HBV‐endemic areas.</p> </sec> </abstract>