Comparison of cytokine gene polymorphism in drug‐induced maculopapular eruption, urticaria and drug reaction with eosinophilia and systemic symptoms (DRESS). (6th March 2013)

• Record Type: Journal Article
• Authors: Barbaud, A.; Waton, J.; Herbeth, B.; Bursztejn, A.C.; Bollaert, M.; Schmutz, J.L.; Guéant‐Rodriguez, R.M.; Namour, F.; Guéant, J.L.; Aimone‐Gastin, I.
• Is Part Of: Journal of the European Academy of Dermatology and Venereology. Volume 28:Number 4(2014:Apr.)
• Page Start: 491
• Page End: 499
• Publication Date: 2013-03-06
• Subjects: Dermatology -- Periodicals; Sexually transmitted diseases -- Periodicals; 616.5
• DOI: 10.1111/jdv.12130
• Languages: English
• ISSNs: 0926-9959

Abstract

<abstract abstract-type="main" xml:lang="en" id="jdv12130-abs-0001"> <title>Abstract</title> <sec id="jdv12130-sec-0001" sec-type="section"> <title>Background</title> <p>Polymorphisms of genes controlling cytokine production have not been studied in the genetic susceptibility to cutaneous adverse drug reactions (CADR).</p> </sec> <sec id="jdv12130-sec-0002" sec-type="section"> <title>Objectives</title> <p>The objective was to determine whether polymorphisms in nine cytokine genes were associated to the occurrence of drug reaction with eosinophilia and systemic symptoms (DRESS) compared to drug‐induced maculopapular eruption or urticaria and to controls without drug intolerance.</p> </sec> <sec id="jdv12130-sec-0003" sec-type="section"> <title>Methods</title> <p>Results from 118 patients with a well‐defined CADR were compared to 236 controls without drug intolerance living in the same area of France. We assessed nine polymorphisms: interleukin (IL)1‐alpha‐889C>T (rs 1800587), IL1‐beta‐511C>T (rs 16944), IL1‐RN intron‐2‐VNTR (rs2234663), IL2‐330T>G (rs 2069762), IL4‐33C>T (rs 2070874), IL5‐745C>T (rs 2069812), IL10‐592C>A (rs 1800872), IL16‐295T>C (rs 4778889) and tumour necrosis factor‐alpha‐308G>A (rs 1800629).</p> </sec> <sec id="jdv12130-sec-0004" sec-type="section"> <title>Results</title> <p>Three polymorphisms exhibited a significant association with CADR (<italic>P</italic> < 0.05). The combination of the IL1‐RN‐A2 and IL1‐beta‐511C alleles was statistically different between cases and controls (<italic>P</italic> = 0.007) and the A2C haplotype was associated with susceptibility to CADR, particularly in drug reaction with eosinophilia and systemic symptoms (DRESS) patients (odds ratio = 3.22; 95% confidence interval = 1.23–8.41; <italic>P</italic> = 0.016). The frequency of the IL10‐592A allele was higher in DRESS patients than in controls (dominant model CC vs. CA + AA:<italic> P</italic> = 0.035). These abnormalities were not evident in maculopapular eruptions or urticaria.</p> </sec> <sec id="jdv12130-sec-0005" sec-type="section"> <title>Conclusions</title> <p>This is the first study showing that IL1‐cluster polymorphisms and haplotypes and the IL10‐592A allele (a low IL10 producer) are associated with DRESS. These gene variants may decrease drug tolerance and promote herpes virus reactivation.</p> </sec> </abstract>