Sulcus fluid bone marker levels and the outcome of surgical treatment of peri‐implantitis. (April 2014)

• Record Type: Journal Article
• Authors: Wohlfahrt, Johan C.; Aass, Anne M.; Granfeldt, Finn; Lyngstadaas, Ståle P.; Reseland, Janne E.
• Is Part Of: Journal of clinical periodontology. Volume 41:Number 4(2014:Apr.)
• Page Start: 424
• Page End: 431
• Publication Date: 2014-04
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12229
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12229-abs-0001"> <title>Abstract</title> <sec id="jcpe12229-sec-0001" sec-type="section"> <title>Aim</title> <p>To analyse change in selected bone markers in peri‐implant sulcus fluid (PISF) sampled before treatment and after 12 months and test correlation with change in disease progression.</p> </sec> <sec id="jcpe12229-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Peri‐implant sulcus fluid was sampled from 32 patients in a randomized, clinical study comparing peri‐implant defect re‐construction with or without porous titanium granules. Matrix metalloproteinase 8 levels were measured using the Quantikine Human Total MMP‐8 (DMP800) ELISA. Multianalyte profiling of the level of bone markers [interleukin‐6, osteprotegerin (OPG), osteocalcin, leptin, osteopontin, parathyroid hormone, tumour necrosis factor‐α, adiponectin and insulin] was performed by Luminex using Human Bone Panel IB. Changes in bone marker levels were compared and correlation with clinical findings was tested.</p> </sec> <sec id="jcpe12229-sec-0003" sec-type="section"> <title>Results</title> <p>No differences in clinical parameter or bone marker levels between test and control group were found. When comparing bone marker levels irrespective of treatment allocation between baseline and 12 months, a significant reduction in total protein, matrix metalloproteinase ‐8, interleukin‐6, OPG, leptin and adiponectin were demonstrated. Positive correlations were found between the reduction in interleukin‐6 (<italic>r</italic> = 0.43), insulin (<italic>r</italic> = 0.38) and matrix metalloproteinase‐8 (<italic>r</italic> = 0.47) concentration, and probing pocket depth reduction.</p> </sec> <sec id="jcpe12229-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Peri‐implantitis surgical treatment induced some reduction of the studied bone markers. Conclusive evidence for correlation between change in bone marker concentrations with disease resolution was not found.</p> </sec> </abstract>