Ring‐Closing Metathesis Enabled Efficient Synthesis of γ‐Butenolide Antifungal Agent (−)‐Incrustoporin and its Analogues. Issue 1 (20th December 2013)

• Record Type: Journal Article
• Authors: Fernandes, Rodney A.; Patil, Pradnya H.; Chowdhury, Asim K.
• Is Part Of: Asian journal of organic chemistry. Volume 3:Issue 1(2014:Jan.)
• Page Start: 58
• Page End: 62
• Publication Date: 2013-12-20
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201300216
• Languages: English
• ISSNs: 2193-5807

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient synthesis of the antifungal agent (−)‐incrustoporin and analogues based on ring‐closing metathesis (RCM) is described. The ready availability of various allyl alcohols through the Sharpless kinetic resolution and esterification with a variety of substituted aryl acetic acids, followed by α‐methylenation and final RCM to get the targets makes this explored strategy suitable for rapid development of analogues.</p> </abstract>