Orthostatic Blood Pressure Dysregulation and Polymorphisms of β‐Adrenergic Receptor Genes in Hypertensive Patients. Issue 3 (19th February 2014)

• Record Type: Journal Article
• Authors: Gao, Ying; Lin, Yahui; Sun, Kai; Wang, Yibo; Chen, Jingzhou; Wang, Hu; Zhou, Xianliang; Fan, Xiaohan; Hui, Rutai
• Is Part Of: Journal of clinical hypertension. Volume 16:Issue 3(2014:Mar.)
• Page Start: 207
• Page End: 213
• Publication Date: 2014-02-19
• Subjects: Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.12272
• Languages: English
• ISSNs: 1524-6175

Abstract

<abstract abstract-type="main" id="jch12272-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. The association between polymorphisms of beta‐adrenergic receptor (<italic>β‐AR</italic>) genes and orthostatic blood pressure dysregulation in hypertensive patients was investigated. Two polymorphisms of <italic>β<sub>1</sub>‐AR</italic> (Arg389/Gly) and <italic>β<sub>2</sub>‐AR</italic> (Arg16/Gly) were genotyped in untreated hypertensive patients and normotensive patients. In patients with untreated hypertension, the frequency of <italic>β<sub>1</sub>‐AR</italic> Gly389 homozygote was significantly higher in patients with orthostatic hypotension (OH) (<italic>P</italic><.0001) and lower in patients with orthostatic hypertension (OHT) (<italic>P</italic>=.002) as compared with patients with orthostatic normotension (ONT) even after Bonferroni correction. After analysis by sex and adjustment for conventional risk factors, the <italic>β<sub>1</sub>‐AR</italic> Gly389 homozygote conferred about a 3‐fold risk of OH and independently predicted a 6.5 mm Hg greater orthostatic SBP decrease (GG −8.9±13 mm Hg vs CC+CG −2.4±12 mm Hg, <italic>P<</italic>.001) only in female hypertensive patients. The association of <italic>β<sub>2</sub>‐AR</italic> Arg16/Gly with OH was not significant after adjustment for conventional risk factors. In normotensive patients, no association was identified between these two polymorphisms and OHT or OH. These results indicated that the <italic>β<sub>1</sub>‐AR</italic> Arg389/Gly polymorphism may be associated with increased risk of OH in female hypertensive patients.</p> </abstract>