Moderate to vigorous physical activity interactions with genetic variants and body mass index in a large US ethnically diverse cohort. Issue 2 (25th March 2013)

• Record Type: Journal Article
• Authors: Richardson, A. S.; North, K. E.; Graff, M.; Young, K. M.; Mohlke, K. L.; Lange, L. A.; Lange, E. M.; Harris, K. M.; Gordon‐Larsen, P.
• Is Part Of: Pediatric obesity. Volume 9:Issue 2(2014:Apr.)
• Page Start: e35
• Page End: e46
• Publication Date: 2013-03-25
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/j.2047-6310.2013.00152.x
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo152-sec-0001" sec-type="section"> <title>What is already known about this subject</title> <p> <list id="ijpo152-list-0001" list-type="bullet"> <list-item> <p>Genome‐Wide Association Studies have successfully identified numerous genetic loci that influence body mass index in European‐descent middle‐aged adults.</p> </list-item> <list-item> <p>Adolescence is a high‐risk period for the development of adult obesity and severe obesity.</p> </list-item> <list-item> <p>Physical activity is one of the most promising behavioural candidates for preventing and reducing weight gain, particularly among youth.</p> </list-item> </list> </p> </sec> <sec id="ijpo152-sec-5001" sec-type="section"> <title>What this study adds</title> <p> <list id="ijpo152-list-0002" list-type="bullet"> <list-item> <p>An examination of the joint association between 41 of the well‐established obesity susceptibility single‐nucleotide polymorphisms with <5 vs. ≥5 bouts of moderate to vigorous physical activity (MVPA) per week in relation to body mass index (BMI)‐for‐age <italic>Z</italic>‐score in a nationally representative sample of European American, African–American and Hispanic American adolescents.</p> </list-item> <list-item> <p>Three nominally significant interactions (<italic>P</italic> < 0.05) varied by race/ethnicity.</p> </list-item> <list-item> <p>Overall, the estimated effect of the risk allele on BMI‐for‐age <italic>Z</italic>‐score was greater in individuals with <5 than those with ≥5 bouts MVPA per week.</p> </list-item> </list> </p> </sec> <sec id="ijpo152-sec-0002" sec-type="section"> <title>Background</title> <p>Little is known about the interaction between genetic and behavioural factors during lifecycle risk periods for obesity and how associations vary across race/ethnicity.</p> </sec> <sec id="ijpo152-sec-0003" sec-type="section"> <title>Objective</title> <p>The objective of this study was to examine joint associations of adiposity‐related single‐nucleotide polymorphisms (SNPs) and moderate to vigorous physical activity (MVPA) with body mass index (BMI) in a diverse adolescent cohort.</p> </sec> <sec id="ijpo152-sec-0004" sec-type="section"> <title>Methods</title> <p>Using data from the National Longitudinal Study of Adolescent Health (<italic>n</italic> = 8113: Wave II 1996; ages 12–21, Wave III; ages 18–27), we assessed interactions of 41 well‐established SNPs and MVPA with BMI‐for‐age <italic>Z</italic>‐scores in European Americans (EA; <italic>n</italic> = 5077), African–Americans (AA; <italic>n</italic> = 1736) and Hispanic Americans (HA; <italic>n</italic> = 1300).</p> </sec> <sec id="ijpo152-sec-0005" sec-type="section"> <title>Results</title> <p>Of 97 assessed, we found nominally significant SNP–MVPA interactions on BMI‐for‐age <italic>Z</italic>‐score in EA at <italic>GNPDA2</italic> and <italic>FTO</italic> and in HA at <italic>LZTR2/SEC16B</italic>. In EA, the estimated effect of the <italic>FTO</italic> risk allele on BMI‐for‐age <italic>Z</italic>‐score was lower (β = −0.13; 95% confidence interval [CI]: 0.08, 0.18) in individuals with ≥5 vs. <5 (β = 0.24; CI: 0.16, 0.32) bouts of MVPA per week (<italic>P</italic> for interaction 0.02). Race/ethnicity‐pooled meta‐analysis showed nominally significant interactions for SNPs at <italic>TFAP2B</italic>, <italic>POC5</italic> and <italic>LYPLAL1</italic>.</p> </sec> <sec id="ijpo152-sec-0006" sec-type="section"> <title>Conclusions</title> <p>High MVPA may attenuate underlying genetic risk for obesity during adolescence, a high‐risk period for adult obesity.</p> </sec> </abstract>