Safety in the Use of Dexmedetomidine (Precedex) for Deep Brain Stimulation Surgery: Our Experience in 23 Randomized Patients. Issue 5 (10th July 2012)

• Record Type: Journal Article
• Authors: Sassi, Marco; Zekaj, Edvin; Grotta, Alessandra; Pollini, Alberto; Pellanda, Armando; Borroni, Massimo; Pacchetti, Claudio; Menghetti, Claudia; Porta, Mauro; Servello, Domenico
• Is Part Of: Neuromodulaton. Volume 16:Issue 5(2013)
• Page Start: 401
• Page End: 406
• Publication Date: 2012-07-10
• Subjects: Central nervous system -- Physiology -- Periodicals; Central nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/j.1525-1403.2012.00483.x
• Languages: English
• ISSNs: 1094-7159

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objective:</bold> Evaluation of safety and efficacy of dexmedetomidine in deep brain stimulation (DBS) surgery.</p> <p> <bold>Materials and Methods:</bold> A cohort of 23 patients, candidates for DBS for Parkinson's disease, Tourette syndrome, or obsessive‐compulsive disorder, was randomized in two groups: dexmedetomidine group and control group. Standard anesthesiologic parameters were recorded and analyzed, together with the need for other medications. A ten‐degree scale (visual analog scale) assessing patient discomfort during DBS also was recorded at the end of surgery.</p> <p> <bold>Results:</bold> The results demonstrated good stability of intraoperative monitoring: no respiratory depression and good overall cooperation with the neurologist, while no side‐effects were recorded.</p> <p> <bold>Conclusions:</bold> Our conclusion is that dexmedetomidine should be considered as a valuable option for sedation in poorly collaborating patients undergoing DBS surgery.</p> </abstract>