Association of GATA4 sequence variation with alcohol dependence. (2nd August 2012)

• Record Type: Journal Article
• Authors: Karpyak, Victor M.; Winham, Stacey J.; Biernacka, Joanna M.; Cunningham, Julie M.; Lewis, Kriste A.; Geske, Jennifer R.; Colby, Colin L.; Abulseoud, Osama A.; Hall‐Flavin, Daniel K.; Loukianova, Larissa L.; Schneekloth, Terry D.; Frye, Mark A.; Heit, John A.; Mrazek, David A.
• Is Part Of: Addiction biology. Volume 19:Number 2(2014:Mar.)
• Page Start: 312
• Page End: 315
• Publication Date: 2012-08-02
• Subjects: Substance abuse -- Periodicals; Substance abuse -- Physiological aspects -- Periodicals; Substance-Related Disorders -- periodicals; 616.86
• DOI: 10.1111/j.1369-1600.2012.00482.x
• Languages: English
• ISSNs: 1355-6215

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>To further explore reports of association of alcohol dependence and response to acamprosate treatment with the <italic>GATA4</italic> rs13273672 single nucleotide polymorphism (SNP), we genotyped this and 10 other <italic>GATA4</italic> SNPs in 816 alcohol‐dependent cases and 1248 controls. We tested for association of alcohol dependence with the 11 SNPs individually and performed a global test for association using a principle components analysis. Our analyses demonstrate significant association between <italic>GATA4</italic> and alcohol dependence at the gene level (<italic>P </italic>= 0.009) but no association with rs13273672. Further studies are needed to identify potential causal <italic>GATA4</italic> variation(s) and the functional mechanism(s) contributing to this association.</p> </abstract>