N‐(2‐methyl‐6‐benzoxazolyl)‐N′‐1, 5‐naphthyridin‐4‐yl urea (SB334867), a hypocretin receptor‐1 antagonist, preferentially prevents ethanol seeking: comparison with natural reward seeking. (26th July 2012)

• Record Type: Journal Article
• Authors: Martin‐Fardon, Rémi; Weiss, Friedbert
• Is Part Of: Addiction biology. Volume 19:Number 2(2014:Mar.)
• Page Start: 233
• Page End: 236
• Publication Date: 2012-07-26
• Subjects: Substance abuse -- Periodicals; Substance abuse -- Physiological aspects -- Periodicals; Substance-Related Disorders -- periodicals; 616.86
• DOI: 10.1111/j.1369-1600.2012.00480.x
• Languages: English
• ISSNs: 1355-6215

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Orexins/hypocretins (Orx/Hcrt) are hypothalamic peptides that regulate a wide range of physiological processes and have been shown to be recruited by drugs of abuse. This study was designed to test the effect of the specific Orx/Hcrt receptor‐1 (Hcrt‐r1) antagonist, <italic>N</italic>‐(2‐methyl‐6‐benzoxazolyl)‐<italic>N</italic>′‐1, 5‐naphthyridin‐4‐yl urea (SB334867), on reinstatement elicited by ethanol (EtOH)‐associated stimuli versus stimuli associated with a conventional reinforcer [i.e. SuperSac, consisting of 3% glucose and 0.125% saccharin (w/v)]. SB334867 (1–10 mg/kg, i.p.) dose‐dependently reduced reinstatement induced by the EtOH‐ but not SuperSac‐associated stimuli. These findings support a differential role of Hcrt‐r1 in mediating EtOH seeking versus natural reward seeking.</p> </abstract>