Human parainfluenza virus in patients with influenza‐like illness from Central and South America during 2006–2010. Issue 2 (28th November 2013)

• Record Type: Journal Article
• Authors: Villaran, Manuel V.; García, Josefina; Gomez, Jorge; Arango, Ana E.; Gonzales, Marina; Chicaiza, Wilson; Alemán, Washington; Lorenzana de Rivera, Ivette; Sanchez, Felix; Aguayo, Nicolas; Kochel, Tadeusz J.; Halsey, Eric S.
• Is Part Of: Influenza and other respiratory viruses. Volume 8:Issue 2(2014:Mar.)
• Page Start: 217
• Page End: 227
• Publication Date: 2013-11-28
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12211
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" id="irv12211-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="irv12211-sec-0001" sec-type="section"> <title>Background</title> <p>Human parainfluenza viruses (HPIVs) are common viral causes of community‐acquired pneumonia, particularly in children. The four types of HPIV have world‐wide distribution; however, limited information exists about the epidemiological profile of HPIV in Latin‐America.</p> </sec> <sec id="irv12211-sec-0002" sec-type="section"> <title>Objective</title> <p>Provide epidemiologic and phylogenetic information about HPIVs that circulated in Latin America between 2006 and 2010 to better characterize the extent and variability of this respiratory virus in the region.</p> </sec> <sec id="irv12211-sec-0003" sec-type="section"> <title>Methods</title> <p>Oropharyngeal swabs, demographic data and clinical characteristics were obtained from individuals with influenza‐like illness in 10 Latin‐American countries between 2006–2010. Specimens were analyzed with culture and molecular methods.</p> </sec> <sec id="irv12211-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 30 561 individuals were enrolled; 991 (3·2%) were HPIV positive. Most infected participants were male (53·7%) and under 5 years of age (68·7%). The HPIV type most frequently isolated was HPIV‐3 (403, 40·7%). In 66/2007 (3·3%) hospitalized individuals, HPIV was identified. The most frequent symptoms at enrollment were cough and rhinorrhea. We identified certain patterns for HPIV‐1, ‐2 and ‐3 in specific cities. Phylogenetic analysis revealed a homogeneous distribution in the region.</p> </sec> <sec id="irv12211-sec-0005" sec-type="section"> <title>Conclusions</title> <p>In the current scenario, no vaccine or treatment is available for this pathogen. Our results contribute to the scarce epidemiologic and phylogenetic information of HPIV in the region that could support the development of specific management.</p> </sec> </abstract>