An Enantiodivergent Synthesis of (+)‐ and (−)‐Centrolobines by Asymmetric Esterification Catalyzed by (R)‐(+)‐N‐Methylbenzoguanidine ((R)‐NMBG). Issue 11 (2nd October 2013)

• Record Type: Journal Article
• Authors: Nakata, Kenya; Tokumaru, Tatsuya; Iwamoto, Hidetoshi; Nishigaichi, Yutaka; Shiina, Isamu
• Is Part Of: Asian journal of organic chemistry. Volume 2:Issue 11(2013:Nov.)
• Page Start: 920
• Page End: 922
• Publication Date: 2013-10-02
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201300139
• Languages: English
• ISSNs: 2193-5807

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Seventh heaven</bold>: The enantiodivergent synthesis of (+)‐ and (−)‐centrolobines was achieved in a total of seven steps by using an asymmetric esterification in the presence of catalytic (<italic>R</italic>)‐(+)‐<italic>N</italic>‐methylbenzoguanidine as the key reaction.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6sfrw8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>