DEFB1 gene 5′ untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians. (12th September 2013)

• Record Type: Journal Article
• Authors: Wilson, T. J.; Jobim, M.; Segat, L.; Bianco, A. M.; Salim, P. H.; Portela, P.; Jobim, L. F.; Damin, D. C.; Schwartsmann, G.; Roesler, R.; Crovella, S.
• Is Part Of: International journal of immunogenetics. Volume 41:Number 2(2014:Apr.)
• Page Start: 138
• Page End: 142
• Publication Date: 2013-09-12
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12089
• Languages: English
• ISSNs: 1744-3121

Abstract

<abstract abstract-type="main" id="iji12089-abs-0001"> <title>Summary</title> <p>The possible association of three <italic>DEFB1</italic> gene polymorphisms with susceptibility to develop ulcerative colitis (UC) and Crohn's disease (CD) was investigated in Brazilian patients and controls. Although a clear and strong association between functional 5′‐UTR <italic>DEFB1</italic> SNPs and susceptibility/protection to IBDs cannot be drawn, our results suggest a possible involvement of <italic>DEFB1</italic> gene in inflammatory bowel diseases, especially with the colonic localization of Crohn's disease.</p> </abstract>