Prevalence of Helicobacter pylori Infection by Birth Year and Geographic Area in Japan. Issue 2 (10th February 2014)

• Record Type: Journal Article
• Authors: Ueda, Junko; Gosho, Masahiko; Inui, Yoshikatsu; Matsuda, Toru; Sakakibara, Masatoshi; Mabe, Katsuhiro; Nakajima, Shigemi; Shimoyama, Tadashi; Yasuda, Mitsugi; Kawai, Takashi; Murakami, Kazunari; Kamada, Tomoari; Mizuno, Motowo; Kikuchi, Shogo; Lin, Yingsong; Kato, Mototsugu
• Is Part Of: Helicobacter. Volume 19:Issue 2(2014:Apr.)
• Page Start: 105
• Page End: 110
• Publication Date: 2014-02-10
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12110
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12110-abs-0001"> <title>Abstract</title> <sec id="hel12110-sec-0001" sec-type="section"> <title>Background</title> <p> <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>)‐related diseases are responsible for a tremendous amount of morbidity and mortality in Japan. We estimated the prevalence of <italic>H. pylori</italic> infection by sex, birth year, and geographic area among Japanese adults.</p> </sec> <sec id="hel12110-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>This cross‐sectional study included 14, 716 subjects aged 20 years or more who underwent a health checkup between May 1997 and March 2013 in seven geographic areas throughout Japan. Relevant information on the demographics and status of <italic>H. pylori</italic> infection was retrieved from the electronic database. The univariate log‐binominal regression model was used to estimate the prevalence of <italic>H. pylori</italic> infection, taking birth year into consideration. The multivariate log‐binominal regression model was used to compare the prevalence of <italic>H. pylori</italic> infection between seven geographic areas.</p> </sec> <sec id="hel12110-sec-0003" sec-type="section"> <title>Results</title> <p>The overall prevalence of <italic>H. pylori</italic> infection was 37.6% in women and 43.2% in men. Among seven geographic areas, Hokkaido showed the lowest prevalence (29.4%), while Yamagata Prefecture represented the highest (54.5%). The prevalence of H. pylori infection was highest in the 1940–1949 birth cohort and then decreased in the ensuing birth cohorts; the risk ratio (RR) was 0.85 (95% confidence interval (CI) 0.84–0.87) for changes in the 10‐year birth cohort. Individuals in Yamagata Prefecture had the highest RR of acquiring H. pylori infection in all three birth cohorts (RR = 1.53 for 1940, RR = 1.69 for 1950, and RR = 1.85 for 1960) when compared with those in Hokkaido.</p> </sec> <sec id="hel12110-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The prevalence of <italic>H. pylori</italic> infection increases with age and exhibits geographic variation in Japan. There has been a striking decrease in the prevalence of <italic>H. pylori</italic> infection, especially in younger Japanese populations.</p> </sec> </abstract>