5, 10‐Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene–environment interaction analysis in non‐syndromic cleft lip/palate. (24th January 2014)

• Record Type: Journal Article
• Authors: Estandia‐Ortega, Bernardette; Velázquez‐Aragón, José A.; Alcántara‐Ortigoza, Miguel A.; Reyna‐Fabian, Miriam E.; Villagómez‐Martínez, Sandra; González‐del Angel, Ariadna
• Is Part Of: European journal of oral sciences. Volume 122:Number 2(2014:Apr.)
• Page Start: 109
• Page End: 113
• Publication Date: 2014-01-24
• Subjects: Dentistry -- Periodicals; Oral medicine -- Periodicals; 617.6005
• DOI: 10.1111/eos.12114
• Languages: English
• ISSNs: 0909-8836

Abstract

<abstract abstract-type="main" id="eos12114-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Non‐syndromic cleft lip/palate (NSCL/P) is a common congenital defect in Mexico. Periconceptional intake of folic acid (FA) may reduce the risk of this malformation. Although the 5, 10‐methylenetetrahydrofolate reductase (MTHFR) enzyme participates in folate metabolism, several studies failed to find any association between NSCL/P and the <italic>MTHFR</italic> C677T and A1298C polymorphisms. However, interactions among NSCL/P, <italic> MTHFR</italic> gene polymorphisms, and FA intake have not been explored in Mexican populations. This case–control study included 132 patients with NSCL/P and 370 controls from Mexico City. Maternal FA consumption during pregnancy was examined, as were the <italic>MTHFR</italic> C677T and A1298C polymorphisms and gene–FA interactions. Maternal FA intake during the periconceptional period was lower in cases (1.5%) than in controls (13%), with the risk of delivering a child with NSCL/P lower in mothers who consumed FA (OR = 0.29, 95% CI: 0.19–0.44). In addition, the risk of NSCL/P was lower in children with the TT than the CC genotype of <italic>MTHFR</italic> C677T (OR = 0.39, 95% CI: 0.23–0.68), after Bonferroni correction and exclusion of stratification. No evidence of gene–FA interaction was found. These results indicate that maternal FA intake and the TT genotype of the <italic>MTHFR</italic> C677T polymorphism in children independently reduced the risk of NSCL/P in our population.</p> </abstract>