Clinical association between serum γ‐glutamyltransferase levels and the development of insulin resistance in Korean men: a 5‐year follow‐up study. Issue 4 (9th October 2013)

• Record Type: Journal Article
• Authors: Ryoo, J.‐H.; Oh, C.‐M.; Kim, H. S.; Park, S. K.; Choi, J.‐M.
• Is Part Of: Diabetic medicine. Volume 31:Issue 4(2014:Apr.)
• Page Start: 455
• Page End: 461
• Publication Date: 2013-10-09
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12315
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12315-abs-0001"> <title>Abstract</title> <sec id="dme12315-sec-0001" sec-type="section"> <title>Aims</title> <p>In recent years, γ‐glutamyltransferase has emerged as a predictor of cardiovascular disease, Type 2 diabetes mellitus, the metabolic syndrome and hypertension. However, it is not yet certain whether γ‐glutamyltransferase is a predictor for insulin resistance. The aim of this study was to examine the longitudinal association between baseline γ‐glutamyltransferase level and the development of insulin resistance in Korean men.</p> </sec> <sec id="dme12315-sec-0002" sec-type="section"> <title>Methods</title> <p>We performed a prospective cohort study, involving 22 931 healthy Korean men without baseline insulin resistance (homeostasis model assessment of insulin resistance, HOMA‐IR < 2.7) for 5 years. We checked the HOMA‐IR serially to monitor the development of insulin resistance (incidence of HOMA‐IR ≥ 2.7). A Cox proportional hazards model was used to determine hazard ratios for insulin resistance by quartile groups of baseline serum γ‐glutamyltransferase levels.</p> </sec> <sec id="dme12315-sec-0003" sec-type="section"> <title>Results</title> <p>During 81 208.6 person‐years of follow‐up, 3856 (16.8%) cases of insulin resistance developed between 2006 and 2010. After adjusting for multiple covariates, including baseline HOMA‐IR, the hazard ratios (95% CI) for incident insulin resistance comparing the second to the fourth quartile of baseline serum γ‐glutamyltransferase levels with the first quartile were 1.19 (1.06–1.33), 1.38 (1.23‐1.53) and 1.58 (1.41‐1.77), respectively (<italic>P</italic> for trend < 0.001).</p> </sec> <sec id="dme12315-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our findings show that serum γ‐glutamyltransferase level could be a predictor of the development of insulin resistance in Korean men.</p> </sec> </abstract>