Air‐oxidized linalool elicits eczema in allergic patients – a repeated open application test study. (March 2014)

• Record Type: Journal Article
• Authors: Andersch Björkman, Ylva; Hagvall, Lina; Siwmark, Charlotte; Niklasson, Bo; Karlberg, Ann‐Therese; Bråred Christensson, Johanna
• Is Part Of: Contact dermatitis. Volume 70:Number 3(2014:Mar.)
• Page Start: 129
• Page End: 138
• Publication Date: 2014-03
• Subjects: Contact dermatitis -- Periodicals; 616.51
• DOI: 10.1111/cod.12163
• Languages: English
• ISSNs: 0105-1873

Abstract

<abstract abstract-type="main" id="cod12163-abs-0001"> <title>Summary</title> <sec id="cod12163-sec-0001" sec-type="section"> <title>Background</title> <p id="cod12163-para-0001">Linalool is a commonly used fragrance terpene that forms potent sensitizers upon oxidation. In a recent multicentre study, we found that 7% of 2900 patients showed positive patch test reactions to oxidized linalool at 6.0%. No elicitation studies have been performed.</p> </sec> <sec id="cod12163-sec-0002" sec-type="section"> <title>Objective</title> <p id="cod12163-para-0002">To identify threshold concentrations for elicitation of allergic contact dermatitis caused by oxidized linalool in allergic individuals with repeated exposures.</p> </sec> <sec id="cod12163-sec-0003" sec-type="section"> <title>Methods</title> <p id="cod12163-para-0003">Repeated open application tests were performed in 6 participants previously diagnosed with contact allergy to oxidized linalool. Creams containing 3.0%, 1.0% and 0.30% oxidized linalool (corresponding to 0.56%, 0.19% and 0.056% linalool hydroperoxides, respectively) and 'fine fragrance' containing 1.0%, 0.30% and 0.10% oxidized linalool (corresponding to 0.19%, 0.056% and 0.019% linalool hydroperoxides, respectively) were used twice daily for up to 3 weeks. Patch testing with a dilution series of oxidized linalool was performed.</p> </sec> <sec id="cod12163-sec-0004" sec-type="section"> <title>Results</title> <p id="cod12163-para-0004">Five of 6 participants reacted to the cream containing 3% oxidized linalool. With 1% oxidized linalool, a reaction was seen in 3 (cream) and 4 (fine fragrance) participants, respectively. With 0.3% oxidized linalool, 2 (cream) and 1 (fine fragrance) participants reacted.</p> </sec> <sec id="cod12163-sec-0005" sec-type="section"> <title>Conclusion</title> <p id="cod12163-para-0005">Repeated exposure to low concentrations of oxidized linalool can elicit allergic contact dermatitis in previously sensitized individuals.</p> </sec> </abstract>