Autoantibodies in chronic inflammatory demyelinating polyneuropathy: Specificities and clinical relevance. Issue 1 (February 2014)

• Record Type: Journal Article
• Authors: Kusunoki, Susumu
• Is Part Of: Clinical & experimental neuroimmunology. Volume 5:Issue 1(2014)
• Page Start: 8
• Page End: 9
• Publication Date: 2014-02
• Subjects: 616.80479
• DOI: 10.1111/cen3.12101
• Languages: English
• ISSNs: 1759-1961

Abstract

<abstract abstract-type="main" id="cen312101-abs-0001"> <title>Abstract</title> <p>Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic autoimmune neuropathy, of which the precise pathogenetic mechanisms have not yet been elucidated. Recently, the elevated titer of the antibodies to contactin‐1, a protein in axoglial junction, has been reported in a subset of CIDP patients. The antibody‐positive patients shared common clinical features. The antibodies to contactin‐1 might be a good serological marker, and possibly have a pathogenic role in a subgroup of CIDP patients. Examination of the serum antibodies against glycolipids, myelin proteins and proteins in axoglial junctions for the same cohort of patients should be carried out in future.</p> </abstract>