Design, Synthesis, and Biological Evaluation of Andrographolide Derivatives as Potent Hepatoprotective Agents. (26th December 2013)

• Record Type: Journal Article
• Authors: Tang, Chunlei; Gu, Guolong; Wang, Bin; Deng, Xin; Zhu, Xiaoyun; Qian, Hai; Huang, Wenlong
• Is Part Of: Chemical biology & drug design. Volume 83:Number 3(2014:Mar.)
• Page Start: 324
• Page End: 333
• Publication Date: 2013-12-26
• Subjects: Drugs -- Design -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; 615.19005
• DOI: 10.1111/cbdd.12246
• Languages: English
• ISSNs: 1747-0277

Abstract

<abstract abstract-type="main" id="cbdd12246-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Poor water solubility limits the clinical use of andrographolide and its derivatives. In an attempt to develop potent hepatoprotective drugs, a strategy was proposed to improve the aqueous solubility of andrographolide. Ten andrographolide derivatives were designed, synthesized, evaluated for aqueous solubility and <italic>in vivo</italic> hepatoprotective activity against CCl₄‐induced liver injury in mice. As expected, the aqueous solubility of synthetic derivatives was effectively improved. All compounds demonstrated the effect of different degrees in improving the liver enzyme (ALT and AST) activity, especially the most promising compound <bold>9d</bold> significantly improved liver enzyme activity, with high potency to be a new lead.</p> </abstract>