Enantioselective Synthesis of Azaflavanones Using Organocatalytic 6‐endo Aza‐Michael Addition. Issue 5 (12th March 2014)

• Record Type: Journal Article
• Authors: Cheng, Shuanghua; Zhao, Lili; Yu, Shouyun
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 5(2014)
• Page Start: 982
• Page End: 986
• Publication Date: 2014-03-12
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300920
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A method to prepare highly enantioenriched azaflavanones using an organocatalytic 6‐<italic>endo</italic> aza‐Michael addition has been described. A variety of 2‐aryl‐, 2‐vinyl‐ and 2‐methylazaflavanones were prepared in good yields (53–84%) and excellent enantioselectivities (97.6:2.4 to 99.3:0.7 <italic>er</italic>).</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sr9zvsc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>