A Rhodium‐Catalyzed Cascade Cyclization: Direct Synthesis of N‐Substituted Phthalimides from Isocyanates and Benzoic Acids. Issue 4 (20th February 2014)

• Record Type: Journal Article
• Authors: Shi, Xian‐Ying; Renzetti, Andrea; Kundu, Soumen; Li, Chao‐Jun
• Is Part Of: Advanced synthesis & catalysis. Volume 356:Issue 4(2014)
• Page Start: 723
• Page End: 728
• Publication Date: 2014-02-20
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300834
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A rhodium(III)‐catalyzed amidation between benzoic acids and isocyanates <italic>via</italic> direct functionalization of an <italic>ortho</italic> CH bond followed by intramolecular cyclization is described. This cascade cyclization affords <italic>N</italic>‐substituted phthalimides in one step in 26–91% yields. The reaction is highly atom‐economical, since no theoretical waste except for water is generated in the reaction.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4sx5zzd4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>