Obese children without comorbidities have impaired microvascular endothelial function. (17th January 2014)

• Record Type: Journal Article
• Authors: Hedvall Kallerman, P; Hagman, E; Edstedt Bonamy, A‐K; Zemack, H; Marcus, C; Norman, M; Westerståhl, M
• Is Part Of: Acta pædiatrica. Volume 103:Number 4(2014:Apr.)
• Page Start: 411
• Page End: 417
• Publication Date: 2014-01-17
• Subjects: Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.12549
• Languages: English
• ISSNs: 0803-5253

Abstract

<abstract abstract-type="main" id="apa12549-abs-0001"> <title>Abstract</title> <sec id="apa12549-sec-0001" sec-type="section"> <title>Aim</title> <p>The aim was to test acetylcholine‐induced endothelium‐dependent vasodilatation in obese children without comorbidities, compared with normal weight controls, and to analyse associations between vasodilatation and other potential risk factors.</p> </sec> <sec id="apa12549-sec-0002" sec-type="section"> <title>Methods</title> <p>Endothelium‐dependent vasodilatation was induced by transdermal iontophoresis of acetylcholine in 54 obese children (8.3–18.2 years old, 41% girls) and 44 normal weight controls (7.5–20.2 years old, 82% girls), and the subsequent change in perfusion was measured with laser Doppler flowmetry. In a subgroup of the obese children, associations between acetylcholine‐induced vasodilatation and blood lipids, glucose/insulin metabolism, inflammation, 24‐h ambulatory blood pressure (ABP), cardiovascular fitness and duration of obesity were evaluated.</p> </sec> <sec id="apa12549-sec-0003" sec-type="section"> <title>Results</title> <p>We found a lower endothelium‐dependent vasodilatory response to acetylcholine in the obese children than the controls (p<italic> </italic><<italic> </italic>0.001). The peak perfusion response was 33% lower in obese children (p<italic> </italic>=<italic> </italic>0.001). There was a trend towards lower vasodilatation in obese children with higher levels of triglycerides (p<italic> </italic>=<italic> </italic>0.07). Children with the shortest duration of obesity exhibited the lowest vasodilatation (p<italic> </italic>=<italic> </italic>0.03). No associations were found between 24‐h ABP, cardiovascular fitness, inflammation and glucose/insulin metabolism.</p> </sec> <sec id="apa12549-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Obese children without comorbidities have significantly impaired microvascular endothelial function. The children who had been obese for a longer time seemed less affected.</p> </sec> </abstract>