Cerebral maturation on amplitude‐integrated electroencephalography and perinatal exposures in preterm infants. (20th December 2013)

• Record Type: Journal Article
• Authors: Reynolds, Lauren C; Pineda, Roberta G; Mathur, Amit; Vavasseur, Claudine; Shah, Divyen K; Liao, Steve; Inder, Terrie
• Is Part Of: Acta pædiatrica. Volume 103:Number 3(2014:Mar.)
• Page Start: e96
• Page End: e100
• Publication Date: 2013-12-20
• Subjects: Pediatrics -- Periodicals; Pediatrics; 618.92
• DOI: 10.1111/apa.12485
• Languages: English
• ISSNs: 0803-5253

Abstract

<abstract abstract-type="main" id="apa12485-abs-0001"> <title>Abstract</title> <sec id="apa12485-sec-0001" sec-type="section"> <title>Aim</title> </sec> <sec id="apa12485-sec-0002" sec-type="section"> <p>To determine the associations between perinatal exposures, cerebral maturation on amplitude‐integrated encephalography (aEEG) and outcome.</p> </sec> <sec id="apa12485-sec-0003" sec-type="section"> <title>Methods</title> <p>During this prospective cohort study, 136 infants ≤30 weeks estimated gestational age received 4 h of aEEG at four time points (between the first 2 weeks of life and term‐equivalent age) during hospitalisation. Perinatal factors were documented. Associations between perinatal exposures and Burdjalov‐scores were investigated. Neurodevelopmental outcome was assessed at the age of two.</p> </sec> <sec id="apa12485-sec-0004" sec-type="section"> <title>Results</title> <p>Immature cyclicity on the initial aEEG recording was associated with higher CRIB score (p = 0.01), vaginal delivery (p = 0.02), male gender (p < 0.01) and death (p = 0.01). Perinatal factors associated with lower Burdjalov‐scores included cerebral injury (p < 0.01), sepsis (p < 0.01), lower caffeine dose (p = 0.006), prolonged mechanical ventilation (p = 0.002) and death (p < 0.01). Burdjalov‐scores at 30 (<italic>β </italic>= 2.62, p < 0.01) and 34 weeks postmenstrual age (<italic>β </italic>= 2.89, p = 0.05) predicted motor scores.</p> </sec> <sec id="apa12485-sec-0005" sec-type="section"> <title>Conclusion</title> <p>aEEG measures of cyclicity and Burdjalov‐scores in the first 6 weeks of life, with an emphasis on 30 and 34 weeks postmenstrual age, demonstrated associations with perinatal factors known to predict adverse neurodevelopmental outcome.</p> </sec> </abstract>