Copper‐Catalyzed Domino Synthesis of 4‐Oxopyrimido[1, 2‐a]indole Derivatives. Issue 14 (2nd October 2013)

• Record Type: Journal Article
• Authors: Wang, Yuyuan; Wang, Ruji; Jiang, Yuyang; Tan, Chunyan; Fu, Hua
• Is Part Of: Advanced synthesis & catalysis. Volume 355:Issue 14/15(2013)
• Page Start: 2928
• Page End: 2935
• Publication Date: 2013-10-02
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201300475
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel, convenient and efficient copper‐catalyzed domino method for the synthesis of 4‐oxopyrimido[1, 2‐<italic>a</italic>]indole derivatives has been developed, and the corresponding target products were obtained in moderate to good yields. The domino reactions involved sequential copper‐catalyzed intermolecular C‐arylation, intramolecular addition of NH to nitrile and nucleophilic attack of amino to carbonyl, and the obtained <italic>N</italic>‐(2‐halophenyl)‐3‐oxoalkanamides carry various functional groups.</p> <p> <boxed-text content-type="graphic" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t381qz3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> </abstract>