Mitogen‐activated protein kinases in gliomas and correlation with patients' prognosis. (20th September 2013)

• Record Type: Journal Article
• Authors: Zolota, V.; Sirinian, C.; Kefalopoulou, Z.; Panagiotopoulos, V.; Spinos, P.; Argyriou, A. A.; Kalofonos, H. P.
• Is Part Of: Acta neurologica Scandinavica. Volume 129:Number 4(2014:Apr.)
• Page Start: 226
• Page End: 233
• Publication Date: 2013-09-20
• Subjects: Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.12175
• Languages: English
• ISSNs: 0001-6314

Abstract

<abstract abstract-type="main" id="ane12175-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ane12175-sec-0001" sec-type="section"> <title>Objective</title> <p>We examined the activation of the mitogen‐activated protein kinases (MAPKs) signaling pathway in a cohort of brain gliomas, by taking advantage of a series of phosphorylation state‐specific antibodies against phospho‐p44/42(ERK1/2), phospho‐p38, and phospho‐JNK. Potential correlations between expression profiles of phospho‐p44/42(ERK1/2), phospho‐p38, and phospho‐JNK and tumor grade, age, gender, overall survival, and Ki‐67 status were also explored.</p> </sec> <sec id="ane12175-sec-0002" sec-type="section"> <title>Methods</title> <p>Immunohistochemistry was performed in formalin‐fixed, paraffin‐embedded tissues of 87 serial brain biopsies sequentially obtained for diagnostic purposes in a period of 9 years (2000–2008) from an equal number of patients with low‐ and high‐grade gliomas.</p> </sec> <sec id="ane12175-sec-0003" sec-type="section"> <title>Results</title> <p>Higher expression of all proteins in high‐grade gliomas was documented. The univariate analysis revealed that high phospho‐p44/42(ERK1/2) and high phospho‐JNK expressions were strongly associated with decreased overall survival. However, the multivariate Cox regression failed to consider those markers as independent prognostic factors.</p> </sec> <sec id="ane12175-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Activation of components of MAPK signaling pathway is associated with overall survival of patients with gliomas, thereby suggesting that the MAPK intermediates seem to play a critical role in the biologic behavior of gliomas. Further studies are needed to clarify whether these factors merit to be considered as potential therapeutic targets in future clinical trials.</p> </sec> </abstract>