A role of FCER1A and FCER2 polymorphisms in IgE regulation. Issue 2 (20th December 2013)

• Record Type: Journal Article
• Authors: Sharma, V.; Michel, S.; Gaertner, V.; Franke, A.; Vogelberg, C.; von, A.; Bufe, A.; Heinzmann, A.; Laub, O.; Rietschel, E.; Simma, B.; Frischer, T.; Genuneit, J.; Potaczek, D. P.; Kabesch, M.
• Is Part Of: Allergy. Volume 69:Issue 2(2014:Feb.)
• Page Start: 231
• Page End: 236
• Publication Date: 2013-12-20
• Subjects: Allergy -- Periodicals; 616.97
• DOI: 10.1111/all.12336
• Languages: English
• ISSNs: 0105-4538

Abstract

<abstract abstract-type="main" id="all12336-abs-0001"> <title>Abstract</title> <sec id="all12336-sec-0001" sec-type="section"> <title>Background</title> <p>Both <italic>FCER2</italic> and <italic>FCER1A</italic> encode subunits of IgE receptors. Variants in <italic>FCER1A</italic> were previously identified as major determinants of IgE levels in genome‐wide association studies.</p> </sec> <sec id="all12336-sec-0002" sec-type="section"> <title>Methods</title> <p>Here we investigated in detail whether <italic>FCER2</italic> polymorphisms affect IgE levels alone and/or by interaction with <italic>FCER1A</italic> polymorphisms. To cover the genetic information of <italic>FCER2</italic>, 21 single‐nucleotide polymorphisms (SNPs) were genotyped by Illumina HumanHap300 BeadChip (5 SNPs) and the matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS; 14 SNPs) in at least 1303 Caucasian children (651 asthmatics) (ISAAC II/ MAGICS population); genotypes of two SNPs were imputed.</p> </sec> <sec id="all12336-sec-0003" sec-type="section"> <title>Results</title> <p>SNP rs3760687 showed the most consistent effect on total serum IgE levels (b [SE] = −0.38 [0.16]; <italic>P</italic> = 0.016), while <italic>FCER2</italic> polymorphisms in general were predominantly associated with mildly‐to‐moderately increased IgE levels (50th and 66th percentiles). Gene‐by‐gene interaction analysis suggests that <italic>FCER2</italic> polymorphism rs3760687 influences IgE levels mainly in individuals not homozygous for the risk allele of <italic>FCER1A</italic> polymorphism rs2427837, which belongs to the major IgE‐determining tagging bin in the population.</p> </sec> <sec id="all12336-sec-0004" sec-type="section"> <title>Conclusion</title> <p> <italic>FCER2</italic> polymorphism rs3760687 affects moderately elevated total serum IgE levels, especially in the absence of homozygosity for the risk allele of <italic>FCER1A </italic>SNP rs2427837.</p> </sec> </abstract>