Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis. (6th December 2013)

• Record Type: Journal Article
• Authors: Li, Jie; Chen, Yang; Wei, Shixiu; Wu, Hongbo; Liu, Chengjun; Huang, Qiaoying; Li, Liuming; Hu, Yanling
• Is Part Of: Annals of human genetics. Volume 78:Number 2(2014:Mar.)
• Page Start: 104
• Page End: 116
• Publication Date: 2013-12-06
• Subjects: Human genetics -- Periodicals; 599.935
• DOI: 10.1111/ahg.12048
• Languages: English
• ISSNs: 0003-4800

Abstract

<abstract abstract-type="main"> <title>Summary</title> <p>A relationship between endometriosis and tumor necrosis factor (<italic>TNF‐α</italic>) and interleukin‐6 (<italic>IL‐6</italic>) gene polymorphisms has been raised for Asians. However, this topic is controversial. This study was a meta‐analysis to explore whether <italic>TNF‐α/IL‐6</italic> gene polymorphisms were associated with a risk of endometriosis in Asians. By searching PubMed, HuGENet, and China National Knowledge Infrastructure (CNKI) databases, 17 studies were identified and included (3372 cases and 4008 controls). The odds ratio (OR) with 95% confidence interval (CI) was used to assess the association between <italic>TNF‐α/IL‐6</italic> gene polymorphisms and endometriosis risk. An association of <italic>TNF‐α</italic> gene <italic>‐1031T/C</italic> polymorphism with endometriosis was found (<italic>TT + TC</italic> vs. <italic>CC</italic>: OR 0.50, 95% CI 0.30–0.82, <italic>I</italic><sup>2</sup> = 37.1%, <italic>P</italic> = 0.20; TT vs. CC: OR 0.50, 95% CI 0.30–0.82, <italic>I</italic><sup>2</sup> = 43.0%, <italic>P</italic> = 0.173; <italic>TC</italic> vs. <italic>CC</italic>: OR 0.49, 95% CI 0.29–0.83, <italic>I</italic><sup>2</sup> = 10.6%, <italic>P</italic> = 0.327). In addition, <italic>TNF‐α‐238A/G</italic> and <italic>IL‐6 ‐174C/G</italic> gene polymorphisms were also likely to be associated with endometriosis in Asians. For the TNF‐α‐238A/G gene polymorphism, the OR was 1.577 (95% CI: 1.01–2.48). For the <italic>IL‐6 ‐174C/G</italic> gene polymorphism, the OR was 1.554 (95% CI: 1.04–2.31). No associations were detected between the <italic>TNF‐α‐308A/G</italic> and <italic>IL‐6 ‐634C/G</italic> polymorphisms and susceptibility to endometriosis. Our results indicate that the <italic>TNF‐α</italic> gene <italic>‐1031T/C</italic> polymorphism can reduce the risk of endometriosis, but for Asians, <italic>TNF‐α‐238A/G</italic> and <italic>IL‐6 ‐174C/G</italic> gene polymorphisms may be a risk factor for endometriosis. No association was found for the <italic>TNF‐α‐308A/G</italic> and <italic>IL‐6 ‐634C/G</italic> gene polymorphisms.</p> </abstract>