The route less taken: pulmonary models of enteric Gram‐negative infection. Issue 2 (21st November 2013)

• Record Type: Journal Article
• Authors: Fisher, Michael L.; Sun, Wei; Curtiss, Roy
• Is Part Of: Pathogens and disease. Volume 70:Issue 2(2014:Mar.)
• Page Start: 99
• Page End: 109
• Publication Date: 2013-11-21
• Subjects: Medical microbiology -- Periodicals; Pathogenic microorganisms -- Periodicals; Communicable diseases -- Microbiology -- Periodicals; Communicable diseases -- Pathogenesis -- Periodicals; Host-parasite relationships -- Periodicals; Systems biology -- Periodicals; 616.904105
• DOI: 10.1111/2049-632X.12109
• Languages: English
• ISSNs: 2049-632X

Abstract

<abstract abstract-type="main" id="fim12109-abs-0001"> <title>Abstract</title> <p>Many pathogens are capable of causing a fulminant infection in pulmonary tissues of mammals. Animal models have provided an extensive understanding of the genetic and molecular mechanisms of bacterial pathogenesis as well as host immune response in the lungs. Many clinically relevant Gram‐negative bacteria are host‐restricted. Thus, the powerful, informative tools of mouse models are not available for study with these organisms. However, over the past 30 years, enterprising work has demonstrated the utility of pulmonary infection with enteric pathogens. Such infection models have increased our understanding host–pathogen interactions in these organisms. Here, we provide a review and comparison of lung models of infection with enteric, Gram‐negative bacteria relative to naturally occurring lung pathogens.</p> </abstract>