First report of the predominance of clonal complex 398 Staphylococcus aureus strains in osteomyelitis complicating diabetic foot ulcers: a national French study. (2nd October 2013)

• Record Type: Journal Article
• Authors: Senneville, E.; Brière, M.; Neut, C.; Messad, N.; Lina, G.; Richard, J.‐L.; Sotto, A.; Lavigne, J.‐P.; Tassios, P.
• Is Part Of: Clinical microbiology and infection. Volume 20:Number 4(2014:Apr.)
• Page Start: O274
• Page End: O277
• Publication Date: 2013-10-02
• Subjects: Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1111/1469-0691.12375
• Languages: English
• ISSNs: 1198-743X

Abstract

<abstract abstract-type="main" id="clm12375-abs-0001"> <title>Abstract</title> <p> <italic>Staphylococcus aureus</italic> is the most common pathogen cultured from diabetic foot infection including diabetic foot osteomyelitis. This French multicentre study determined the genetic content of <italic>S. aureus</italic> isolated from 157 consecutive cases admitted to 12 diabetic foot centres between 2008 and 2011. We describe for the first time the emergence of the CC398 methicillin‐susceptible <italic>S. aureus</italic> clone, the main clone in diabetic foot osteomyelitis, and its tropism for bone. This clone spreads to humans from an animal source through its intrinsic virulence. This adaptation of <italic>S. aureus</italic> isolates looks to be a worrisome problem and should be carefully monitored.</p> </abstract>