Enhanced Tumor Accumulation of Sub‐2 nm Gold Nanoclusters for Cancer Radiation Therapy. Issue 1 (22nd July 2013)

• Record Type: Journal Article
• Authors: Zhang, Xiao‐Dong; Chen, Jie; Luo, Zhentao; Wu, Di; Shen, Xiu; Song, Sha‐Sha; Sun, Yuan‐Ming; Liu, Pei‐Xun; Zhao, Jing; Huo, Shuaidong; Fan, Saijun; Fan, Feiyue; Liang, Xing‐Jie; Xie, Jianping
• Is Part Of: Advanced healthcare materials. Volume 3:Issue 1(2014:Jan.)
• Page Start: 133
• Page End: 141
• Publication Date: 2013-07-22
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300189
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A new type of metabolizable and efficient radiosensitizers for cancer radiotherapy is presented by combining ultrasmall Au nanoclusters (NCs, &lt;2 nm) with biocompatible coating ligands (glutathione, GSH). The new nanoconstruct (GSH‐coated Au₂₅ NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small‐sized GSH‐Au₂₅ NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au₂₅ NCs in the body.</p> </abstract>