Antibody‐Functionalized Magnetic Polymersomes: In vivo Targeting and Imaging of Bone Metastases using High Resolution MRI. Issue 11 (19th April 2013)

• Record Type: Journal Article
• Authors: Pourtau, Line; Oliveira, Hugo; Thevenot, Julie; Wan, Yali; Brisson, Alain R.; Sandre, Olivier; Miraux, Sylvain; Thiaudiere, Eric; Lecommandoux, Sébastien
• Is Part Of: Advanced healthcare materials. Volume 2:Issue 11(2013:Nov.)
• Page Start: 1420
• Page End: 1424
• Publication Date: 2013-04-19
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201300061
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Multifunctional polymersomes</bold> loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody‐labeled polymersomes at the tumor site. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t6qt36t" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>