Antifungal Activity of 10 Guadeloupean Plants. (27th December 2012)

• Record Type: Journal Article
• Authors: Biabiany, Murielle; Roumy, Vincent; Hennebelle, Thierry; François, Nadine; Sendid, Boualem; Pottier, Muriel; Aliouat, El Moukhtar; Rouaud, Isabelle; Lohézic‐Le Dévéhat, Françoise; Joseph, Henry; Bourgeois, Paul; Sahpaz, Sevser; Bailleul, François
• Is Part Of: Phytotherapy research. Volume 27:Number 11(2013:Nov.)
• Page Start: 1640
• Page End: 1645
• Publication Date: 2012-12-27
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.4906
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection <italic>Pneumocystis</italic> pneumonia. For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five <italic>Candida</italic> species, <italic>Scytalidium dimidiatum</italic>, a <italic>Malassezia</italic> sp. strain and <italic>Pneumocystis carinii</italic>. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of <italic>Bursera simaruba</italic>, <italic>Cedrela odorata</italic>, <italic>Enterolobium cyclocarpum</italic> and <italic>Pluchea carolinensis</italic> have interesting activities and could be good candidates for developing antifungal formulations. Copyright © 2012 John Wiley &amp; Sons, Ltd.</p> </abstract>