Clinical Study to Assess the Efficacy and Safety of a Citrus Polyphenolic Extract of Red Orange, Grapefruit, and Orange (Sinetrol‐XPur) on Weight Management and Metabolic Parameters in Healthy Overweight Individuals. (3rd April 2013)

• Record Type: Journal Article
• Authors: Dallas, Constantin; Gerbi, Alain; Elbez, Yves; Caillard, Philippe; Zamaria, Nicolas; Cloarec, Maurice
• Is Part Of: Phytotherapy research. Volume 28:Number 2(2014:Feb.)
• Page Start: 212
• Page End: 218
• Publication Date: 2013-04-03
• Subjects: Materia medica, Vegetable -- Periodicals; Botany, Medical -- Periodicals; Medicinal plants -- Periodicals; Plant Extracts -- therapeutic use -- Periodicals; Plants, Medicinal -- Periodicals; 581.634
• DOI: 10.1002/ptr.4981
• Languages: English
• ISSNs: 0951-418X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The present study investigated the efficacy and safety effects of Sinetrol‐XPur (polyphenolic citrus dry extract) in weight management; metabolic parameters; and inflammatory, glycemic and oxidative status. In a 12‐week, randomized, double‐blind, placebo‐controlled trial, Sinetrol‐XPur was given to overweight subjects twice daily with meals in the tested group (<italic>N</italic> = 47) versus a placebo group (<italic>N</italic> = 48). Waist and hip circumference and abdominal fat were decreased in the Sinetrol‐XPur group as compared with the placebo group (<italic>p</italic> < 0.0001) (−5.71% vs −1.56% for waist, −4.71% vs −1.35% for hip and −9.73% vs −3.18% for fat). Inflammatory markers were reduced (C‐reactive protein: −22.87% vs +61%; fibrinogen: −19.93% vs −1.61%, <italic>p</italic> < 0.01). Oxidative stress was lowered as seen by the reduction of malondialdehyde (−14.03% vs 2.76%) and the increase in superoxide dismutase and glutathione (17.38% vs 2.19% and 4.63% vs −2.36%, respectively, <italic>p</italic> < 0.01). No adverse effects were observed. Kidney, liver, and lipid panels remained unchanged. These results indicated that Sinetrol‐XPur supplementation is a viable option for reducing abdominal fat, waist and hip circumference, and body weight and for improving inflammatory, glycemic, and oxidative status in healthy overweight individuals. Copyright © 2013 John Wiley & Sons, Ltd.</p> </abstract>