High SPDEF may identify patients who will have a prolonged response to androgen deprivation therapy. Issue 5 (27th December 2013)

• Record Type: Journal Article
• Authors: Haller, Andrew C.; Tan, Wei; Payne‐Ondracek, Rochelle; Underwood, Willie; Tian, Lili; Morrison, Carl; Li, Fengzhi
• Is Part Of: Prostate. Volume 74:Issue 5(2014)
• Page Start: 509
• Page End: 519
• Publication Date: 2013-12-27
• Subjects: Prostate -- Diseases -- Periodicals; 616
• DOI: 10.1002/pros.22770
• Languages: English
• ISSNs: 0270-4137

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pros22770-sec-0001" sec-type="section"> <title>BACKGROUND</title> <p>Due to the indolent nature of prostate cancer, new prognostic measures are needed to identify patients with life threatening disease. SAM pointed domain‐containing Ets transcription factor (SPDEF) has been associated with good prognosis and demonstrates an intimate relationship with the androgen receptor (AR), however its role in prostate cancer progression remains unclear.</p> </sec> <sec id="pros22770-sec-0002" sec-type="section"> <title>METHODS</title> <p>A tissue microarray constructed from cores of 713 consecutive radical prostatectomy specimens were immunohistochemically stained for SPDEF and correlated with progression free and metastatic free survival. In vitro studies assessed growth rate, migration, and sensitivity to bicalutamide to explore mechanisms behind the tissue microarray observations.</p> </sec> <sec id="pros22770-sec-0003" sec-type="section"> <title>RESULTS</title> <p>Patients with high SPDEF demonstrate longer metastases free survival after receiving the standard of care (HR = 9.80, <italic>P</italic> = 0.006). SPDEF expression corresponded with bicalutamide growth inhibition and apoptosis induction in all cell lines studied. In addition, a feedforward loop of AR‐SPEF expression regulation is observed.</p> </sec> <sec id="pros22770-sec-0004" sec-type="section"> <title>CONCLUSIONS</title> <p>SPDEF may be clinically useful to identify patients who will have extended benefits from androgen deprivation therapy. In vitro observations suggest SPDEF mediates initial sensitivity to androgen deprivation therapy through both AR regulation and downstream events. <italic>Prostate 74:509–519, 2014</italic>. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>