Analysis of serum insulin growth factor‐1 concentrations in localized osteosarcoma: A children's oncology group study. Issue 4 (31st October 2013)

• Record Type: Journal Article
• Authors: Borinstein, Scott C.; Barkauskas, Donald A.; Bernstein, Mark; Goorin, Allen; Gorlick, Richard; Krailo, Mark; Schwartz, Cindy L.; Wexler, Leonard H.; Toretsky, Jeffrey A.
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 4(2014:Apr.)
• Page Start: 749
• Page End: 752
• Publication Date: 2013-10-31
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24778
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24778-sec-0001" sec-type="section"> <p>To investigate the role of insulin‐like growth factor‐1 (IGF‐1), in localized osteosarcoma, serum levels of IGF‐1, IGFBP‐2, and IGFBP‐3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF‐1 and IGFBP‐3 compared to older (<italic>P</italic> &lt; 0.001) along with lower IGFBP‐3:IGF‐1 and IGFBP‐2:IGF‐1 ratios (<italic>P</italic> &lt; 0.001). IGFBP‐2 did not correlate with age (<italic>P</italic> = 0.16), yet IGFBP‐2:IGF‐1 ratios were higher in the younger population (<italic>P</italic> &lt; 0.001). These findings show that older patients have higher concentrations of free IGF‐1. None of IGF‐1, IGFBP‐2, nor IGFBP‐3 concentrations were associated with event‐free nor overall survival. Pediatr Blood Cancer 2014;61:749–752. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>