Concurrent juvenile myelomonocytic leukemia and T‐lymphoblastic lymphoma with a shared missense mutation in NRAS. Issue 5 (8th October 2013)

• Record Type: Journal Article
• Authors: Ly, Brenda; Modi, Arunkumar; Rogers, Heesun J.; Makishima, Hideki; Hanna, Rabi; Cook, James R.; Theil, Karl S.; Maciejewski, Jaroslaw P.
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 5(2014:May)
• Page Start: 946
• Page End: 948
• Publication Date: 2013-10-08
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24797
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24797-sec-0001" sec-type="section"> <p>Single cases of B‐ and T‐lymphoblastic leukemia/lymphoma occurring after remission of JMML, and JMML occurring after remission of B‐lymphoblastic leukemia have been reported in the literature. We present a unique case of a child with concurrent JMML and T‐lymphoblastic lymphoma in which an identical missense mutation in NRAS was found in both the neoplastic JMML and T‐LBL cells. JMML has been considered a stem cell disorder, and our case provides additional molecular evidence for a stem cell lesion underlying the two different disease phenotypes. Pediatr Blood Cancer 2014;61:946–948. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>