Glomerular filtration rate and cardiometabolic risk in an outpatient pediatric population with high prevalence of obesity. (15th October 2013)

• Record Type: Journal Article
• Authors: Di Bonito, Procolo; Sanguigno, Eduardo; Forziato, Claudia; Di Fraia, Teresa; Moio, Nicola; Cavuto, Luigi; Sibilio, Gerolamo; Iardino, Maria Rosaria; Di Carluccio, Carla; Capaldo, Brunella
• Is Part Of: Obesity. Volume 22:Number 2(2014:Feb.)
• Page Start: 585
• Page End: 589
• Publication Date: 2013-10-15
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20497
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20497-sec-0001" sec-type="section"> <title>Objective</title> <p>To evaluate the relationship between estimated glomerular filtration rate (eGFR) and cardiometabolic risk factors (CMRF) in an outpatient pediatric population with high prevalence of obesity.</p> </sec> <sec id="oby20497-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>eGFR was evaluated in 901 children unselected for chronic kidney disease of whom 694 were overweight/obese (6‐16 years) and 207 were age‐ and sex‐matched normal weight (NW). We generated three categories of eGFR: mild‐low eGFR (< 20th percentile), high eGFR (>80th percentile) and intermediate eGFR (20‐80th percentile), considered as the reference category</p> </sec> <sec id="oby20497-sec-0003" sec-type="section"> <title>Results</title> <p>Children with either mild‐low or high eGFR category showed a 2‐4 fold higher Odds ratio of high blood pressure, left ventricular hypertrophy, and microalbuminuria compared with children of the intermediate eGFR category. In addition, children with mild‐low eGFR levels showed a 1.5‐2 fold higher Odds ratio of impaired fasting glucose and high white blood cell count compared with children with intermediate eGFR levels.</p> </sec> <sec id="oby20497-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In outpatient children with high prevalence of obesity, children with either mildly reduced or high eGFR have an increased burden of CMRF. Children with eGFR < 97 mL/min/1.73 m<sup>2</sup> show a worse CMR profile. This finding supports the usefulness to assess eGFR to identify children with unfavorable CMR profile.</p> </sec> </abstract>