Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans. (11th February 2014)

• Record Type: Journal Article
• Authors: Liu, Jiankang; Coady, Sean; Carr, J. Jeffery; Hoffmann, Udo; Taylor, Herman A.; Fox, Caroline S.
• Is Part Of: Obesity. Volume 22:Number 3(2014:Mar.)
• Page Start: 811
• Page End: 818
• Publication Date: 2014-02-11
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20307
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20307-sec-0001" sec-type="section"> <title>Objective</title> <p>To examine the relative association of abdominal visceral adipose tissue (VAT) with cardiometabolic risk factors between African and European Americans.</p> </sec> <sec id="oby20307-sec-0002" sec-type="section"> <title>Methods</title> <p>A cross‐sectional study of 2, 035 African Americans from the Jackson Heart Study (JHS) and 3, 170 European Americans from the Framingham Heart Study (FHS) who underwent computed tomography assessment of VAT and subcutaneous adipose tissue (SAT) was conducted. The FHS participants were weighted to match the age distribution of the JHS participants, and the metabolic risk factors were examined by study groups in relation to VAT.</p> </sec> <sec id="oby20307-sec-0003" sec-type="section"> <title>Results</title> <p>JHS participants had higher rates of obesity, hypertension, diabetes, and metabolic syndrome than FHS participants (all <italic>P</italic> = 0.001). The associations were weaker in JHS women for VAT with blood pressure, triglycerides, HDL‐C, and total cholesterol (<italic>P</italic><sub>interaction</sub> = 0.03‐0.001) than FHS women. In contrast, JHS men had stronger associations for VAT with high triglycerides, low HDL, and metabolic syndrome (all <italic>P</italic><sub>interaction</sub> = 0.001) compared to FHS men. Similar associations and gender patterns existed for SAT with most metabolic risk factors.</p> </sec> <sec id="oby20307-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The relative association between VAT and cardiometabolic risk factors is weaker in JHS women compared to FHS women, whereas stronger associations with triglycerides and HDL were observed in JHS men.</p> </sec> </abstract>