Double‐pulsed diffusional kurtosis imaging. (20th February 2014)

• Record Type: Journal Article
• Authors: Jensen, Jens H.; Hui, Edward S.; Helpern, Joseph A.
• Is Part Of: NMR in biomedicine. Volume 27:Number 4(2014:Apr.)
• Page Start: 363
• Page End: 370
• Publication Date: 2014-02-20
• Subjects: Nuclear magnetic resonance -- Periodicals; Magnetic Resonance Spectroscopy -- Periodicals; 574
• DOI: 10.1002/nbm.3094
• Languages: English
• ISSNs: 0952-3480

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Diffusional kurtosis imaging (DKI) is extended to double‐pulsed‐field‐gradient (d‐PFG) diffusion MRI sequences. This gives a practical approach for acquiring and analyzing d‐PFG data. In particular, the leading d‐PFG effects, beyond what conventional single‐pulsed field gradient (s‐PFG) provides, are interpreted in terms of the kurtosis for a diffusion displacement probability density function (dPDF) in a six‐dimensional (6D) space. The 6D diffusional kurtosis encodes the unique information provided by d‐PFG sequences up to second order in the <italic>b</italic>‐value. This observation leads to a compact expression for the signal magnitude, and it suggests novel data acquisition and analysis methods. Double‐pulsed DKI (DP‐DKI) is demonstrated for <italic>in vivo</italic> mouse brain with d‐PFG data obtained at 7 T. Copyright © 2014 John Wiley &amp; Sons, Ltd.</p> </abstract>